Blood mimicking fluid for in-vitro flow visualization and measurement: A Critical Review of Literature
In orders to understands the cardiovascular diseases, research requires flow measurement and visualization technique, in-vitro. The example of in-vitro method to assess blood flow structure is angiography visualization, particle image velocimetry and laser Doppler velocimetry. Blood mimicking fluids is used for replacement of actual human blood.
Cardiovascular disease such as heart attack, stroke, etc. is the most common death causing disease worldwide. Because of this, intensive and comprehensive research had been conducted to understand the disease for development of treatment strategies and disease management. In-vivo studies for the diseases is being conducted in the past. In-vivo is a method where the testing is being carried out within the living organism. Due to the ethical problem, hygiene problem and expensive costs in-vivo studies causes. Researchers turn to in-vitro studies to have better understandings of the disease. Whereby, in-vitro is a studies where it is conducted outside of a living organism in a controlled environment. In orders to understands the diseases research requires flow measurement and visualization technique, in-vitro. The most common in-vitro experimental method to assess blood flow structure are angiography visualization, particle illumination photography, particle image velocimetry (PIV) and laser Doppler velocimetry. Blood mimicking fluids (BMF) is used for replacement of actual human blood in the studies of blood flow. A critical review of the formulation of blood mimic for in-vitro flow measurement and visualization was made. The systematic method proposed by Denyer and Transfield (2009) is applied. In this systematic method, there are 4 stages. Stage 1: Finding and selecting related publication, Stage 2: Assessing related literature, Stage 3: Analysing selected articles and Stage 4: Reporting and debating the results. It could be concluded that as PIV and Doppler Ultrasound have been used for the fluid measurement for a long time, the new focus is onto the surgical simulation environment employing 3D-printing anatomy. The consideration on non-Newtonian property of blood was observed as an important criteria for blood mimic formulation.